J7-2603 Efficacy of bacteriophages for treatment of extracellular and intracellular bacterial infections of implants

The project is addressing some basic aspects of bacteriophage therapy of prosthetic joint infection (PJI).

The goal of the project is to determine effect of physiological state (including VBNC) of planktonic bacteria cells on lytic bacteriophage efficiency. Furthermore,  we will determine the efficiency of bacteriophages for treatment of biofilms that are formed by selected bacteria species. The project will also determine bacteriophage efficiency in treatment of intracellular infection in primary human cells. Based on obtained results, we will propose an algorithm of PJI treatment using bacteriophages that can serve as a basis for further clinical tests.

The project is cofunded by the Slovenian Research Agency ARRS.