P3-0387 Gut microbiota in health and disease

We set off to study association of gut microbiota with common inflammatory diseases.

Gut microbiota is a complex microbial community with diverse density and composition throughout the digestive system. Healthy microbiota has significant effect on several aspects of human development and physiology, while dysbiotic microbiota has been associated with many acute and chronic diseases. In this research programme we use different – omics approaches to study bacterial, fungal and viral gut microbiota signatures and functional properties in various patient groups, including individuals with inflammatory bowel disease and with non-celiac gluten sensitivity. Another aspect are studies of microbe-microbe interactions and use of in vitro models. Here our main model is Clostridium difficile infection and especially effect of C. difficile on gut microbiota. Additional large part of the work is devoted to characterization of ‘undefined’ OTUs and their potential role as well as isolation of phages and investigation of their contribution in shaping of the intestinal microbial communities.

The project is cofunded by the Slovenian Research Agency ARRS.

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